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91.
Discusses the Dutch health system, focusing on the increasing number of clinical psychologists who are offering their services to the public as private practitioners. This move toward primary health care given by the "first-line psychologist" results from a generalistic frame of reference in which a wide range of psychic, psychosocial, and psychosomatic difficulties are treated with a time-limited framework. In this way, the clinical psychologist contributes to changing the habits and lifestyles of a broad population. Responses to the system are encouraging, and the government has begun to respond positively to the system. (5 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
92.
We describe RTblob, a high speed vision system that detects objects in cluttered scenes based on their color and shape at a speed of over 800 frames/s. Because the system is available as open-source software and relies only on off-the-shelf PC hardware components, it can provide the basis for multiple application scenarios. As an illustrative example, we show how RTblob can be used in a robotic table tennis scenario to estimate ball trajectories through 3D space simultaneously from four cameras images at a speed of 200 Hz.  相似文献   
93.
94.
Crease surfaces describe extremal structures of 3D scalar fields. We present a new region-growing-based approach to the meshless extraction of adaptive nonmanifold valley and ridge surfaces that overcomes limitations of previous approaches by decoupling point seeding and triangulation of the surface. Our method is capable of extracting valley surface skeletons as connected minimum structures. As our algorithm is inherently mesh-free and curvature adaptive, it is suitable for surface construction in fields with an arbitrary neighborhood structure. As an application for insightful visualization with valley surfaces, we choose a low frequency acoustics simulation. We use our valley surface construction approach to visualize the resulting complex-valued scalar pressure field for arbitrary frequencies to identify regions of sound cancellation. This provides an expressive visualization of the topology of wave node and antinode structures in simulated acoustics.  相似文献   
95.
In in-vivo microsystems, one of the components is a biocompatible micropump in order to produce the necessary force to deliver the fluid from the inlet to the outlet. In this contribution, a flexible micropump is fabricated which is aimed to be suitable in drug delivery applications. It provides high degree of biocompatibility, since the only employed materials are implantation grade polydimethylsiloxane elastomer and gold for the electrical interconnects. The working principle of the micropump is based on transverse DC electroosmosis which is a new variant of conventionally applied high voltage DC electroosmosis. This new technique is based on topography irregularities introduced in the channel resulting in a non-uniform charge distribution. The advantage is to drive the micropump using a relatively low DC voltage of 10 V while getting an effective flow speed of 60 μm/s. In order to characterize the flow speed, dyed 3 μm beads are dispersed in the working fluid and their speed is measured by the line scanning technique using a confocal microscope. It is also observed that the flow has a helical profile which is an attractive feature for an efficient micro-mixer in active microfluidics and μ-TAS applications.  相似文献   
96.
Inplane tensile fracture of unnotched and notched thermoset graphite-epoxy and thermoplastic graphite-PEEK composite laminates is examined. Both fibre-dominated quasi-isotropic and matrix dominated ±45 angle-ply layups were investigated.Classical lamination theory predictions of elastic and strength properties of unnotched specimens are compared with experiments. Several notched geometries, i.e. centre-notched, double-edge notched and open-hole specimens subjected to tensile loading to fracture were examined. The notched strength of the quasi-isotropic laminates was analysed by a damage zone model, where damage around the notch is represented by an equivalent crack with cohesive force acting between the crack surfaces.Good agreement between experimental and calculated strength was observed for the graphite-epoxy laminates which failed in a collinear manner. For the graphite-PEEK laminates discrepancies between predicted and experimental strength are related to observed deviations from collinear crack growth. The angle-ply graphite-PEEK laminates showed larger notch sensitivity than the corresponding graphite-epoxy, probably due to less degree of stress relieving damage formation around the notch.  相似文献   
97.
Summary The gelatinized, autoclaved and sodiumhydroxide-treated starch preparations were used and their interaction with soluble pentosans and gliadin was analysed. The molecular sieving technique and optical methods were used to detect the complexes formed. The modified starches formed complexes with both soluble pentosans and gliadin in acidic and neutral media (non-ionic molecular forces being involved). The autoclaved starch showed the highest reactivity. The amylose and amylopectin played different roles in the interactions and the aggregates of amylose with gliadin and amylopectin with soluble pentosans were the prevailing forms present in the complexes. Small quantities of other products were also identified.
Einfluß der hydrothermischen Behandlung auf die physiko-chemischen Eigenschaften des RoggenkornsII. Wechselwirkung der Eiweiß-und Kohlenhydratkomplexe (Modelluntersuchung)
Zusammenfassung Die Wechselwirkungen verkleisterter, autoklavierter und mit Natronlauge behandelter Stärke mit löslichen Pentosanen und Gliadin werden mit Hilfe der Gelpermeation und mit optischen Methoden untersucht. Die modifizierten Stärken bildeten Komplexe mit den Pentosanen und mit Gliadin im sauren und neutralen Medium, autoklavierte Stärke zeigte die hächste Reaktion. Die unterschiedliche Rolle von Amylose und Amylopection zeigte vorherrschend Amylose-Gliadin und Amylopectin-PentosanKomplexe, während andere Komplexe in kleineren Mengen auftraten.
  相似文献   
98.
Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing a stronger proinflammatory influence. One of the systems affected by hypoxia is the CXC chemokine system. This paper reviews all available information on hypoxia-induced changes in the expression of all CXC chemokines (CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL8 (IL-8), CXCL9, CXCL10, CXCL11, CXCL12 (SDF-1), CXCL13, CXCL14, CXCL15, CXCL16, CXCL17) as well as CXC chemokine receptors—CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, CXCR6, CXCR7 and CXCR8. First, we present basic information on the effect of these chemoattractant cytokines on cancer processes. We then discuss the effect of hypoxia-induced changes on CXC chemokine expression on the angiogenesis, lymphangiogenesis and recruitment of various cells to the tumor niche, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), regulatory T cells (Tregs) and tumor-infiltrating lymphocytes (TILs). Finally, the review summarizes data on the use of drugs targeting the CXC chemokine system in cancer therapies.  相似文献   
99.
Cancer-associated fibroblasts (CAFs) are one of the most abundant and critical components of the tumor stroma. CAFs can impact many important steps of cancerogenesis and may also influence treatment resistance. Some of these effects need the direct contact of CAFs and cancer cells, while some involve paracrine signals. In this study, we investigated the ability of head and neck squamous cell carcinomas (HNSCC) patient-derived CAFs to promote or inhibit the colony-forming ability of HNSCC cells. The effect of cisplatin on this promoting or inhibiting influence was also studied. The subsequent analysis focused on changes in the expression of genes associated with cancer progression. We found that cisplatin response in model HNSCC cancer cells was modified by coculture with CAFs, was CAF-specific, and different patient-derived CAFs had a different “sensitizing ratio”. Increased expression of VEGFA, PGE2S, COX2, EGFR, and NANOG in cancer cells was characteristic for the increase of resistance. On the other hand, CCL2 expression was associated with sensitizing effect. Significantly higher amounts of cisplatin were found in CAFs derived from patients who subsequently experienced a recurrence. In conclusion, our results showed that CAFs could promote and/or inhibit colony-forming capability and cisplatin resistance in HNSCC cells via paracrine effects and subsequent changes in gene expression of cancer-associated genes in cancer cells.  相似文献   
100.
With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from n = 82 patients with Dilated Cardiomyopathy (DCM) and n = 51 controls in the screening stage. We identified several metabolites involved in glycolysis and citric acid cycle to be elevated up to 5.7-fold in DCM (p = 1.7 × 10−6). Interestingly, cardiac mRNA and epigenetic changes of genes encoding rate-limiting enzymes of these pathways could also be found and validated in our second stage of metabolite assessment in n = 52 DCM, n = 39 ischemic HF and n = 57 controls. In conclusion, we identified a new set of metabolomic biomarkers for HF. We were able to identify underlying biological cascades that potentially represent suitable intervention targets.  相似文献   
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